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3.1.2 Clinical manifestations of mutual influence The comorbidity of chronic constipation and depression leads to complex clinical presentations, with the two conditions mutually influencing each other to form a vicious cycle that significantly impairs quality of life

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This study has some limitations including that the number of individuals for whom cardiometabolic measures were available in the AEMR and LAAD databases was quite low, with the exception of BP, which prevented us from evaluating the other cardiometabolic outcomes for the BMI and HbA1c subgroups