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The Food and Drug Administration says in its safety profiles of drugs like Ozempic and Wegovy that they should not be taken during pregnancy, noting there is "insufficient data" available

indicated that preoperative treatment with melatonin (10 mg/day, P.O for 30 days) notably raised Nrf2 levels in peripheral blood mononuclear cells of patients undergoing coronary artery bypass grafting (CABG) [208]

Establishing human safety would require controlled ascending-dose trials with systematic adverse-event capture, which have not been completed for either compound as sold