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6 The reason for mitochondrial dysfunction in ASD is unknown, but the fact that only 23% of children with ASD and MD have a known mitochondrial deoxyribonucleic acid (mtDNA) abnormality suggests that MD may be acquired rather than genetic in many ASD cases

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Bozdagi O, Tavassoli T, Buxbaum JD (2013 Apr 27) Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay

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