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Vildagliptin attenuates Huntingtons disease through activation of GLP-1 Receptor/PI3K/Akt/BDNF pathway in 3-Nitropropionic acid rat model
Thorough medical screening is essential before considering combination therapy
The drug is composed of a GLP-1 receptor agonist combined with an inhibitor (antagonist) of another receptor extensively present in the brainthe NMDA receptor
These findings align with evidence that GLP-1 is widely expressed and secreted within the nervous system, supporting potential effects in either the central or peripheral nervous system, the researchers wrote
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