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importante destacar, entretanto, que resultados obtidos em culturas celulares no podem ser extrapolados diretamente para efeitos clnicos em humanos

They also reported that the SCN of rats in the TSI group had increased and decreased Rev-Erb and Bmal1 protein levels, respectively, in addition to neuronal mitochondrial dysfunction, compared with that of rats in the control group

Se excess can further lead to joint pain, muscle weakness, tremor, muscle spasms, ataxia, headache, confusion and memory loss, and, in more severe cases of intoxication, fever, hypotension, abnormal electrocardiogram, cardiac arrest, respiratory arrest, liver toxicity, delirium, coma, and death (51, 65, 66)