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References 1 Journal of Clinical Endocrinology & MetabolismTeichman et al

In that regard, 3,3-dimethyl-1-butanol (DMB), a structural analog of choline has been found to inhibit microbial TMA lyase and reduced TMAO concentrations in mice fed with a choline or L-carnitine rich diet

The study was published in Proceedings of the National Academy of Sciences on March 4, 2026, and was funded by federal research grants from the National Institutes of Health (MD, USA) and private philanthropy

The dosing rationale was determined from the pharmacokinetic profile of mGIPR-Ab following a single ICV-administered dose (Extended Data Fig