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Patients at high risk of hepatotoxicity should have serial APAP level and hepatic function panels measured before the completion of NAC

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This is supported by a strong and intricate network of SA that includes cascades of mitogen-activated protein kinases (MAPK), ROS, calcium ions (Ca 2+ ), nitric oxide (NO), and non-expressor of pathogenesis related protein-1 (NPR1) [38, 39, 40, 41]