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These organometallic azo complexes exhibited activity in PDT, with IC 50 values of 8.014.2 M under visible light (400700 nm, 10 J cm 2 ) in HaCaT cells (MTT assay), whereas they were less cytotoxic in the dark (IC 50 values of 45.061.9 M)

Thus, the analysis of the stylized model reveals that k 1 acts as a control over k 0 , that is, how strongly influences Hcy build up

Chronic inflammation marked by elevated IL-6 disrupts systemic metabolism, activating other pro-inflammatory cytokines like TNF- and IL-1, creating a feedback loop that intensifies inflammation and insulin resistance [11,12]

Mechanistically, RRM2 s oncogenic effects may be mediated through cell cycle regulation and activation of the PI3K/Akt signaling pathway