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In contrast, SGLT2 inhibitor monotherapy is not likely to provide sufcient weight loss for treatment of obesity per se, but could have other benefts in obese patients with comorbidities such as atherosclerotic cardiovascular disease, heart failure, or renal disease

Educational initiatives are valuable for raising awareness

Interestingly, feeding reduces 5-HT responsiveness to GABA inhibitory input, resulting in increased activity of 5-HT neurons [51]

For instance, recent innovations include the approval of oral GLP-1 receptor agonists by the Indonesian Food and Drug Authority, offering patients a non-invasive alternative to injectable therapies