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Moreover, tumor-derived exosomes are able to promote cancer cell migration and metastasis, containing various kinds of integrin, such as exosomal integrins v 6 for prostate cancer (Carmine et al., 2015), 6 4 and 6 1 for lung cancer, and v 5 for liver cancer metastasis (Hoshino et al., 2015)

Hippen: This recent attention to these class of medications and the diseases for which they're being treated can be redirected toward expanding access to RAS inhibition, which is an inexpensive and widely available and well vetted therapy for a wide variety of kidney diseases that would really be an excellent result and a necessary first step to then taking the second step in adding an SGLT2 inhibitor or a GLP1 agonist