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Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens

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10.1001/jamapediatrics.2015.2125 201 MezianeH.SchallerF.BauerS.VillardC.MatarazzoV.RietF.et al

If you have feelings of hopelessness, lack of interest in activities you once enjoyed, mood swings, and a lack of concentration, theres a good chance you may be depressed and it may be more common than you realize