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6, 7, 8 However, it is unclear whether H3K27me3 loss is specific for malignant peripheral nerve sheath tumor, as loss of this protein has also been reported recently in some other sarcomas, especially synovial sarcoma and dermatofibrosarcoma protuberans, and in other malignant spindle cell tumors (rare subset of spindle cell melanoma)

This weight loss is typically gradual, occurring over several months, and can vary from person to person

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This is significant as Schwann cells are the major glial cell type in the peripheral nervous system and play essential roles in nerve function, development, maintenance, and regeneration