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For example, lignans encapsulated in PLGA nanoparticles have shown improved stability and sustained release profiles, ensuring a prolonged therapeutic effect while reducing the dosing frequency [141]

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GLP-1 receptor agonists would not replace these evidence-based interventions, though they might be used concurrently to manage associated metabolic complications such as diabetes, if clinically appropriate and under specialist guidance

In this regard, restoring the basement membrane and preventing the release of melanocytes and melanin into the dermis layer would be essential for long-term treatment of melasma