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Graduated compression garments (20-30 mmHg for upper extremities or 30-40 mmHg for lower extremities) maintain volume reduction achieved through CDT and prevent progression

WHO Consultation on Obesity (1997: Geneva, Switzerland), World Health Organization

In a Phase 2 clinical trial published in 2023 in the New England Journal of Medicine (Jastreboff et al.), participants receiving the highest dose of retatrutide lost up to approximately 24% of their body weight over 48 weeks a notably greater reduction than observed with currently approved agents

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