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Interaction interface of A42 with human Na,K-ATPase studied by MD and ITC and inhibitor screening by MD

The researchers compared exercise alone, exercise plus liraglutide, or liraglutide alone in people without diabetes

The mitochondrial enzyme is derived from the SHMT2 gene located on chromosome 12q13.3 which is composed of 14 exons that generate five alternatively spliced mRNAs that collectively encode three distinct isoforms of the enzyme