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The additional significant decreases in HbA1c and weight remained in favor of tirzepatide after further regression adjustments (Supplementary Table S4)

Researchers choose DES(1-3) when they need a short-acting, potent IGF-1R stimulus for acute signaling studies, and IGF-1 LR3 when sustained receptor activation or reduced dosing frequency is required

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Con el avance de la tecnologa del ADN recombinante en los aos ochenta y noventa, los cientficos disearon anlogos que superaran la limitacin prctica del IGF-1 nativo: su fugaz semivida por el secuestro de las IGFBP