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however, if SGLT2is are not tolerated or are contraindicated, or if eGFR is less than adequate, a GLP-1RA with proven CV benefit can be added (5, In recent guidelines on diabetes, prediabetes, and CVD from the European Society of Cardiology, in collaboration with the EASD, GLP-1RAs with proven CV benefit (liraglutide, semaglutide, and dulaglutide) are recommended as an add-on therapy to metformin ( Mechanisms for the Cardiovascular Benefits of GLP-1RAS Different mechanisms have been proposed to explain the CV benefits elicited by some GLP-1RAs ( 1c , body weight, and systolic blood pressure were also those associated with CV-event reduction

Not all patients will experience constipation while taking GLP-1 medications

Nature 587 , 270274 (2020)

After reconstitution, store at 28C