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Over the last few years, GLP-1 medications like Ozempic, Wegovy and Mounjaro have exploded in popularity for weight loss

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Finally, class 3 compounds, including sitagliptin and teneligliptin, bind to the enzymes active site by anchoring into an accessory binding pocket, referred to as the S 2 extensive side pocket, which is structured by residues Val207, Ser209, Phe357, and Arg358 (87) (Figure 2C)