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Preparation Condition 2 (EDTA deproteinization 80 o C): Heparinization and EDTA-treatment of plasma result in different levels of free GSH, GSSG, and their relative ratio, but does not affect stability of total GSH Suggesting that total GSH is a valid measure in both heparin and EDTA-treated plasma, we found no difference in total GSH between the heparinized plasma (Preparation Condition 1) and EDTA-treated plasma (Preparation Condition 2) stored at 80 o C (Fig

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As expected, they first showed that GPX4 invalidation induced ferroptosis in AML cells that is associated with mitochondrial lipid peroxidation, culminating in antileukemic effects in vitro and in vivo

Feinberg, A., Rebholz, C