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These studies emphasize the significance of OXPHOS in CRC, the role of the reverse Warburg effect, and the metabolic heterogeneity within tumors, offering a comprehensive foundation for further investigation into the metabolic underpinnings of cancer progression and therapeutic resistance

However, the SGLT2i treated cohort were less likely to develop heart failure (RR 0.44 [95% CI 0.23, 0.83] p =0.0092), CKD (RR 0.49 [95% CI 0.28, 0.86] p =0.0118) and be hospitalised for any cause (RR 0.59 [95% CI 0.46, 0.76] p 0.0001) when compared with the GLP-1 RA treated cohort