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Tubular injury decreased sKlotho clearance and was associated with an increased serum sKlotho level in specific CKD models, such as DKD ( Third, the sKlotho level is regulated by several pathological processes, including inflammation, oxidative stress, uremic toxins, and the renin-angiotensin system (RAS), as well as commonly administrated agents, such as phosphate binders or active vitamin D in CKD (Kale et al., 2021

PMCID: PMC12944561