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30.3% at 104 weeks in a BMI 35 extension cohort TRANSCEND-T2D-1 confirmed (topline March 2026, published June 2026): First completed diabetes-specific Phase 3 trial -2.0% HbA1c and 16.8% weight loss in 537 patients, a separate program from TRIUMPH NDA timeline unchanged: industry estimates continue to expect Q4 2026 filing, based on standard practice following TRIUMPH-1's primary readout Timeline unchanged: FDA approval late 2027, market launch Q1Q2 2028 OSA data confirmed (ADA June 6, 2026): TRIUMPH-1's nested sleep apnea substudy showed 60.6% AHI reduction from a severe-OSA baseline of 58.6 events/hour This page updates after every trial announcement bookmark for the latest Introduction Retatrutide stands at the forefront of obesity medicine a first-in-class triple hormone agonist that has demonstrated some of the highest weight loss efficacy ever recorded in clinical trials

The triple-receptor profile, i.e., the potential simultaneous GLP-1R, GIPR, and GCGR agonism, may distinguish it from all prior compounds in the incretin research class as a preclinical tool

Theyre also the first blockbuster drugs to collide with our wellness-obsessed algorithmic age

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