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197 MerR thus became the founding member of the best characterized family of metal-responsive transcription activators (Section 3.2.3)

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Targeted LC-MS/MS is suitable for focused hypotheses requiring rigorous stabilization and quantification, whereas discovery-oriented studies may combine broader profiling with targeted follow-up

Its primary mechanisms include promoting angiogenesis (new blood vessel formation) through VEGF upregulation, modulating the nitric oxide system in a context-dependent manner, activating the FAK-paxillin pathway to drive cell migration and tissue rebuilding, and regulating multiple growth factors (PDGF, TGF-beta, FGF) involved in organized tissue repair