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(1) Regulatory and scalability gaps: standardized protocols for polymeric carrier scalability, sterilization, and long-term stability are lacking, with advanced systems (e.g., PEGylated uricase and biomimetic nanosystems) requiring rigorous immunogenicity (anti-drug antibodies) and cost-effectiveness evaluations
Flucytosine, a synthetic fluorinated pyrimidine used to treat fungal respiratory tract infections, has also been shown to inhibit expression of the pyoverdine siderophore-biosynthesis gene in Pseudomonas aeruginosa , and subsequently suppress pathogenicity in a mouse model of pulmonary infection (Imperi et al., 2013)
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Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
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