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Aminopeptidases can still attack the front end of the peptide

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Research in humans is a bit less impressive Clinical trials in humans A 1981 double-blind study found that chronic insomniac patients found that subjects slept 59% more, shorter sleep latency, and higher sleep efficiency (Schneider 1981) A 1987 double-blind study did not find any statistically significant changes in sleep structure as measured by REM sleep, NREM sleep, or total sleep time (Debellis 1987) A 1992 double-blind study in 14 chronic insomnia patients found higher sleep efficiency and subjectively estimated tiredness decreased to similar levels of healthy subjects in 7 nights of injections (Schneider 1992) There are some limitations to these studies however

only 5 out of the 21 who completed behavior assessments in the placebo group ( p = 0.03)