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Fe 3+ is then reduced to Fe 2+ by the metalloreductase (STEAP3) in endosomes (Figure 2, when an intracellular iron overload occurs, excess iron promotes lipid peroxidation through ROS production and Fenton reaction, thus causing ferroptosis ( TFRC gene encoding TRF1 inhibits erastin-induced ferroptosis and prevents LIP accumulation, while HO-1 promotes ferroptosis by supplementing iron ( TRFC , FTH1 , and FTL ( Autophagy-Dependent Ferroptosis According to current studies, excessive autophagy promotes ferroptosis through iron accumulation or lipid peroxidation

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