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Because they are administered intranasally and act centrally, they avoid the systemic side effects (like blood pressure drops or liver toxicity) associated with systemic peptides
Furthermore, mechanical ventilation is a risk factor for cerebral inflammation and brain injury due both to the pulmonary inflammatory cascade, which migrates systemically to the brain, and to hemodynamic instability for the reduction in cardiac output and high pulmonary resistance caused by the distension of alveoli and compression of pulmonary capillaries 132
Statistical significance is represented in the figures by * p 40 M (Fig
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