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250,252 Tirzepatide and GLP-1 receptor agonists may decrease absorption of oral contraceptives due to delayed gastric emptying, however the evidence is inconsistent.275 As a precaution to avoid unplanned pregnancy, current product information for tirzepatide includes advice that women should switch to a non-oral contraceptive or add a barrier method of contraception for four weeks after initiation, and for four weeks after each dose escalation