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Clinical trials have demonstrated that GLP-1 agonists can reduce the risk of major adverse cardiovascular events such as heart attack, stroke, and cardiovascular death [5, 7]

But, notably, 24 h treatment of NSBSO showed strong cytotoxicity against MCF-7, B16, A549 and 4T1 cells, with IC 50 values of 1.074, 0.844, 1.222 and 4.741 M, respectively, which were much lower than those of reported GSH-responsive peptide derivatives whose IC 50 was greater than 100 M [43]

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The involvement of TRPC channels in lysosomeSRmitochondria crosstalk warrants further investigation to enable targeting of specific TRPC isoforms based on the type of cardiovascular disorder