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biochemically, there is intracellular glutathione (GSH) depletion and decreased activity of glutathione peroxidase 4 (GPX4), lipid peroxides cannot be metabolized by the GPX4-catalyzed reduction reaction, and Fe 2+ oxidizes lipids in a Fenton-like manner, resulting in a large amount of ROS, which promotes ferroptosis 3,6

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Furthermore, mortality was found to be increased in a European population of relatively low selenium status (plasma selenium 89 g/l) on long-term supplementation with 300 g/d (as selenium-yeast) ( Reference Rayman, Winther and Pastor-Barriuso 111 )