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This study measured prefrontal GABA levels and normalized resting-state CBF within the prefrontal area using 1 H-MRS and arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI), respectively

Additionally, the mutant huntingtin protein can impair the function of the transcription factor PGC-1, which is crucial for the regulation of antioxidant defenses and mitochondrial biogenesis