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Funding The authors are grateful to King Saud University, Riyadh, Saudi Arabia, for funding this work through the Ongoing Research Funding program - Research Chairs (ORF-RC-2025-5100)

Key considerations when switching: Allow a washout period based on tirzepatide half-life Start retatrutide at the standard 1mg initiation dose regardless of previous tirzepatide dose Expect renewed GI side effects as the glucagon receptor is a new stimulus Monitor heart rate more carefully during the initial escalation period When tirzepatide is the better choice Tirzepatide remains the superior option in several specific situations