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Decreasing extracellular fluid volume, they might decrease ARR like thiazide diuretics, leading to false-negative screening for PA in patients with T2DM (58)

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A separate meta-analysis pooling data across thousands of patients found tirzepatide users were substantially more likely to reach 10% or greater weight loss compared to semaglutide users

Dual and triple receptor activity (GLP-1, GIP, glucagon) enhances glucose regulation and metabolic outcomes