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Its dual-receptor mechanism distinguishes it from single agonists, and it is commonly utilized in experimental models focused on metabolic processes, peptide-receptor dynamics, and integrated endocrine function
GLP-1Rs are found on various cell types involved in psoriasis, such as macrophages, monocytes, T cells, and keratinocytes [5, 197, 198]
The hallmark features of the subtype include higher expression of Ki67 (hence higher proliferation rate), lower expression of PR, and in some cases, positive status of HER2 and ER, a more aggressive phenotype with higher chances of early relapse, poor prognosis, lower survival rate, lymph node involvement, and metastasis ( 3.3 HER2 subtype This class of tumors is characterized by increased HER2 expression, while ER/PR expression is absent
