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Neoplasia 21 , 11101120 (2019)

Its protective effects arise from several pathways, including direct scavenging of ROS [19], inhibition of the nuclear factor kappa B (NF-B) signaling cascade [19], downregulation of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1) [20], maintenance of mitochondrial membrane stability [21], and inhibition of apoptosis [22]

Recommendations for vitamin supplementation should be individualized and based on blood levels of folate, vitamin B6, and vitamin B12

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