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PMI also has a history of opposing sensible legislation to reduce smoking (opposing plain packaging laws in Australia, challenging tobacco advertising bans in Panama, contesting large health warnings on cigarette packs in Uruguay), and targeting low- and middle-income countries where 80% of the worlds smokers live

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Although IL-18 knockout mice exhibit reduced pulmonary inflammation and emphysema compared to wild-type mice after cigarette smoke [21, 24], pulmonary inflammation occurred independent of NLRP3/caspase-1 axis after four weeks of cigarette smoke exposure [25]

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