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This keeps the transition safe and reduces side effect risks.

Kelly, Joseph, 1962- (Fourth ed.)

It is best to slowly up titrate metformin, starting at 500 mg daily, then increase by 500mg every few days until reaching the target dose of 1000 mg twice per day

Semaglutide activates the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor expressed in pancreatic beta cells, the hypothalamic arcuate nucleus, the area postrema, the nucleus tractus solitarius, and vagal afferent neurons